Basic Information
| LncRNA/CircRNA Name | MSTO2P |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | LCa tissues and corresponding adjacent tissues ,LCa cell lines (H1299, H23, A549) and human bronchial epithelial cells (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | MSTO2P expression in LCa tissues was remarkably higher than that in adjacent tissues.Meanwhile, compared with human bronchial epithelial cells, the level of MSTO2P was remarkably up-regulated in LCa cells. After down-regulating MSTO2P, the cell proliferation ability was weakened, and the protein levels of autophagy-related genes including Agt5, LC-3I, and LC-3II were remarkably down-regulated.MSTO2P promotes LCa cell proliferation and autophagy by up-regulating EZH2. |
| Pubmed ID | 31081092 |
| Year | 2019 |
| Title | LncRNA MSTO2P Promotes Proliferation and Autophagy of Lung Cancer Cells by Up-Regulating EZH2 Expression |
External Links
| Links for MSTO2P | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |