Basic Information
| LncRNA/CircRNA Name | MVIH |
| Synonyms | AK094613 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, etc. |
| Sample | Hepatoma cell line HepG2, liver tumor-derived cell lines SKHEP-1, Huh7 |
| Expression Pattern | up-Regulated |
| Function Description | Our data suggests that deficiency or loss of functional mutations of ARID1A in HCC cells might contribute to the increased activity ofcertain cancer-promoting lncRNAs??IRD1A fragments (A-1, aa 1e310; A-2, aa 311e600; A-3, aa 601e950; A-4, aa 951e1300; A-5, aa 1301e1600; A-6, aa 1601e1900; A-7, aa 1901e2285) were amplified by PCR and subcloned into pGEX-4T-1 vectors (GE Healthcare Life Sciences) to generate recombinant GST-ARID1A fusion proteins. As a subunit of SWI/SNF complex, ARID1A could contribute to its chromatin remodeling activity by recruiting and binding of specific transcription factor and transcriptional coactivator/corepressor complexes.ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer. |
| Pubmed ID | 28716731 |
| Year | 2017 |
| Title | ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. |
External Links
| Links for MVIH | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |