Basic Information
| LncRNA/CircRNA Name | MYCNOS-01 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | rhabdomyosarcoma and neuroblastomacells |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blot, in vitro knockdown |
| Sample | Human ARMS cell line (RMS-01), cell line (RH30), The human NB cell lines (KELLY and SY5Y) |
| Expression Pattern | up-regulated |
| Function Description | MYCNOS-01 transcript levels were generally higher in NB and RMS tumor samples and cell lines with MYCN genomic amplification. RNA interference of MYCNOS-01 expression did not alter MYCN transcript levels but decreased MYCN protein levels. Conversely, MYCN reduction increased MYCNOS-01 transcript levels,creating a negative feedback loop on MYCN protein levels.Reduction of MYCNOS-01 or MYCN expression decreased cell growth in MYCN-amplified alveolar rhabdomyosarcoma and neuroblastoma cell lines.This is consistent with MYCNOS-01-mediated regulation of MYCN contributing to the phenotype observed.Another possibility therefore is that MYCNOS-01 interacts with an miRNA that targets MYCN for degradation, therefore increasing MYCN protein expression by sequestering away a negative regulating factor. |
| Pubmed ID | 29466962 |
| Year | 2018 |
| Title | The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. |
External Links
| Links for MYCNOS-01 | GenBank HGNC NONCODE |
| Links for rhabdomyosarcoma and neuroblastomacells | OMIM COSMIC |