Basic Information
| LncRNA/CircRNA Name | MYOSLID |
| Synonyms | NA |
| Region | GRCh38_2:207239650-207245887 |
| Ensemble | ENSG00000229647 |
| Refseq | NR_146555 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | gastric adenocarcinoma tissues, GC cell lines MKN45, AGS, SGC-7901 and BGC-823, immortal normal gastric epithelial cell line GES-1 |
| Expression Pattern | up-regulated |
| Function Description | the expression of lncRNA MYOSLID was sig nificantly up regulated in GC tissues, and the up regulation of lncRNA MYOSLID in GC was correlated with tumour size, AJCC stage, depth of invasion and survival time.?In addition, apoptosis and growth arrest can be induced in vitro after knockdown of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo.?Further in depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR 29c 3p, resulting in de repression of its downstream target gene MCL 1. |
| Pubmed ID | 31497917 |
| Year | 2019 |
| Title | Long non-coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-29c-3p in gastric cancer |
External Links
| Links for MYOSLID | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |