Basic Information
| LncRNA/CircRNA Name | NALT |
| Synonyms | NALT1, LINC01573, MIR4674HG, NALT |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Cell proliferation assay etc. |
| Sample | bone marrow, T-lymphoma cell |
| Expression Pattern | up-regulated |
| Function Description | We confirmed that up-regulation of NALT associating with NOTCH1 in human samples. Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain. Further xenograft tumor also indicated the growth inducing affection of NALT while could be partial reversed by GSI. |
| Pubmed ID | 26330272 |
| Year | 2015 |
| Title | LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia. |
External Links
| Links for NALT | GenBank HGNC NONCODE |
| Links for acute lymphoblastic leukemia | OMIM COSMIC |