Basic Information
| LncRNA/CircRNA Name | NBAT1 |
| Synonyms | NA |
| Region | GRCh38_6:22134957-22147193 |
| Ensemble | ENSG00000260455 |
| Refseq | NR_034143 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | glioblastoma tissues, cell lines (SVGP12, U251, U87, U373, T98 and LZ229) |
| Expression Pattern | down-regulated |
| Function Description | NBAT1 expressions in glioblastoma tissues were lower than those in normal brain tissues, which was negatively correlated with malignancy degree (p<0.01). Protein levels of Akt were decreased in T98 and U87 cells transfected with si-NBAT1. Meanwhile, proliferation abilities of T98 and U87 cells transfected with si-NBAT1 were significantly decreased as well (p<0.01), which were reversed by transfection of si-Akt. |
| Pubmed ID | 29771423 |
| Year | 2018 |
| Title | Effect of Downregulated lncRNA NBAT1 on the Biological Behavior of Glioblastoma Cells |
External Links
| Links for NBAT1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |