Basic Information
| LncRNA/CircRNA Name | NBAT1 |
| Synonyms | NA |
| Region | GRCh38_6:22134957-22147193 |
| Ensemble | ENSG00000260455 |
| Refseq | NR_034143 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | GC tissues and paracancerous tissues ,Gastric mucosal cell line (GES-1) and GC cell lines(SGC-7901, BGC-823 and MGC-803) |
| Expression Pattern | down-regulated |
| Function Description | NBAT-1 and PTEN were lowly expressed in GC tissues compared with paracancerous tissues and normal gastric tissues.GC patients with stage ????presented lower expression of NBAT-1 than those with stage ????Besides, lower expression of NBAT-1 was found in GC patients with N2-N3 compared with those with N0-N1.NBAT-1 expression was not correlated with TNM stage and distant metastasis in GC patients.Upregulation of NBAT-1 in GC cells inhibited proliferation and arrested cell cycle.NBAT-1 was mainly localized in the cytoplasm of SGC-7901 and MGC-823 cells. NBAT-1 overexpression remarkably upregulated PTEN expression in GC cells. |
| Pubmed ID | 31128020 |
| Year | 2019 |
| Title | Low Expression of lncRNA NBAT-1 Promotes Gastric Cancer Development and Is Associated With Poor Prognosis |
External Links
| Links for NBAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |