Basic Information
| LncRNA/CircRNA Name | NBAT1 |
| Synonyms | NA |
| Region | GRCh38_6:22134957-22147193 |
| Ensemble | ENSG00000260455 |
| Refseq | NR_034143 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cancer |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Human immortalized proximal tubule epithelial cell line (HK-2) and four RCC cell lines (786-O, ACHN, Caki-1, and Caki-2) |
| Expression Pattern | down-regulated |
| Function Description | The expression of NBAT1 and glycogen synthase kinase-3? (GSK-3?)-mediated Wnt/?- catenin-related proteins were measured by quantitative real-time PCR (qRT-PCR) and western blotting in RCC cell lines. Cell viability, migration, and invasion were estimated by CCK-8 and Transwell assay. The association of miR-346 with GSK-3? expression was verified using luciferase assay. NBAT1 was significantly downregulated in RCC cells, and inhibited RCC cell proliferation, migration, and invasion. Furthermore, NBAT1 negatively regulated miR-346 expression. In addition, miR-346 overexpression and the knockdown of GSK-3?, a direct target of miR-346 could overturn the inhibitory effect of NBAT1 on Wnt/?-catenin signaling and cell proliferation, migration, and invasion. |
| Pubmed ID | 31298469 |
| Year | 2019 |
| Title | LncRNA NBAT1 suppresses cell proliferation and migration via miR-346/GSK-3? axis in renal carcinoma |
External Links
| Links for NBAT1 | GenBank HGNC NONCODE |
| Links for renal cancer | OMIM COSMIC |