Basic Information
| LncRNA/CircRNA Name | NBAT1 |
| Synonyms | NA |
| Region | GRCh38_6:22134957-22147193 |
| Ensemble | ENSG00000260455 |
| Refseq | NR_034143 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot |
| Sample | Eca109 and KYSE150 cells, tumor tissues and paired non-tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | lncRNA NBAT-1 levels were lower in EC clinic tissues than in normal samples, and lncRNA NBAT-1 expression was negatively associated with prognosis and TNM stage in EC patients. More importantly, in EC cancer cells, lncRNA NBAT-1 overexpression strongly inhibited cell proliferation, cell growth and tumor glycolysis. Furthermore, a series of rescue experiments were performed to demonstrate that the role of lncRNA NBAT-1 in EC cell proliferation, cell growth and tumor glycolysis was partially dependent on the PKM2 protein, which is a key metabolic enzyme in tumor development. |
| Pubmed ID | 31632565 |
| Year | 2019 |
| Title | LncRNA-NBAT-1 modulates esophageal cancer proliferation via PKM2 |
External Links
| Links for NBAT1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |