Basic Information
| LncRNA/CircRNA Name | NBAT1 |
| Synonyms | NBAT1, CASC14, NBAT-1 |
| Region | GRCh38_6:22134957-22147193 |
| Ensemble | ENSG00000260455 |
| Refseq | NR_034143 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | OS tissues, cell lines (MG63, U2OS, 143b, LM7, KHOS, Nhost) |
| Expression Pattern | down-regulated |
| Function Description | NBAT1 functions as a tumor suppressor in some cancers. However, the expression pattern,the biological function and the mechanisms of NBAT1 in OS progress have not been elucidated. In this study, for the frst time, we found that NBAT1 expression is downregulated in OS tissues and cell lines and is associated with clinical stage, distant metastasis and poor prognosis. Loss- and gain-of-function assays showed that NBAT1 played a negative regulatory role in OS growth and metastasis in vitro and in vivo. Further investigation demonstrated that NBAT1 physically interacted with miR-21 and then suppressed its expression. NBAT1 also regulated downstream genes targeted by miR-21, including PTEN, PDCD4, TPM1 and RECK. |
| Pubmed ID | 29119050 |
| Year | 2017 |
| Title | Long noncoding RNA NBAT1 negatively modulates growth and metastasis of osteosarcoma cells through suppression of miR-21 |
External Links
| Links for NBAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |