Basic Information
| LncRNA/CircRNA Name | NCK1-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | OC tissues,cell lines (SNU119, Caov3, SKOV3, OVCAR-3, SUN8) |
| Expression Pattern | up-regulated |
| Function Description | NCK1-AS1 was markedly upregulated in OC tissues. Besides, we found a dramatic upregulation of NCK1-AS1 in OC cell lines relative to the normal IOSE cells. Interestingly, silencing NCK1-AS1 confined cell proliferation, induced apoptosis and suppressed migration and invasion as well as enhanced DDP sensitivity in OC cells. |
| Pubmed ID | 31761329 |
| Year | 2019 |
| Title | NCK1-AS1 Promotes NCK1 Expression to Facilitate Tumorigenesis and Chemo-Resistance in Ovarian Cancer |
External Links
| Links for NCK1-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |