Basic Information
| LncRNA/CircRNA Name | BC0209135 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | colorectal cancer tissues, cell lines (HCT-116, SW480, SW620, LoVo, SW1116, and HT29) |
| Expression Pattern | down-regulated |
| Function Description | The expression of BC029135 in CRC tissues and cell lines was significantly lower than in adjacent normal tissues. Low BC029135 level in CRS tissues was sig-nificantly associated with a more advanced TNM stage (p = 0.031) and a higher risk of lymph node (p = 0.018) and distant metastases (p=0.034). In addition, overexpression of lncRNA BC029135 could inhibit the invasion of CRC cells. These results indicated that lncRNA BC029135 up-reg-ulation suppresses CRC cell growth and invasion through inhibiting Wnt/?-catenin pathway. |
| Pubmed ID | 29949151 |
| Year | 2018 |
| Title | The Long Noncoding RNA BC0209135 Inhibits the Cell Invasion Through Wnt/?-catenin Signaling in Colorectal Cancer |
External Links
| Links for BC0209135 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |