Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | AML and normal tissues, Human bone marrow hematopoietic stem cell line (CD34) and AML cell lines (KG-1, HL-60, THP-1 and U937) |
| Expression Pattern | down-regulated |
| Function Description | NEAT1 and CREBRF were down-regulated in AML tissues and cells. NEAT1 up-regulation suppressed cell growth, migration and invasion but enhanced apoptosis of AML cells. Inhibition of CREBRF reverted the NEAT1-induced effects on AML cells. Moreover, NEAT1 directly targeted miR-338-3p and miR-338-3p targeted CREBRF. NEAT1/miR-338-3p could affect cellular behaviors of AML cells via the modulation of CREBRF. |
| Pubmed ID | 32280304 |
| Year | 2020 |
| Title | Long non-coding RNA NEAT1/miR-338-3p axis impedes the progression of acute myeloid leukemia via regulating CREBRF |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |