Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | nuclear enriched abundant transcript 1 |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | docetaxel | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR, Western blot, RIP, Dual luciferase reporter assay |
| Sample | PCa tissue samples,PCa cell lines PC3, DU145 and human 293T cells |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was expressed at high levels in docetaxel-resistant PCa clinical samples and related cell lines. When knockdown NEAT1, cell proliferation and invasion in docetaxel-resistant PCa cells in vitro and in vivo were downregulated.NEAT1 exerts oncogenic function in PCa by competitively 'sponging' both miR-34a-5p and miR-204-5p. Inhibition of miR-34a-5p or miR-204-5p expression mimics the docetaxel-resistant activity of NEAT1. |
| Pubmed ID | 31672604 |
| Year | 2020 |
| Title | LncRNA NEAT1 Promotes Docetaxel Resistance in Prostate Cancer by Regulating ACSL4 via Sponging miR-34a-5p and miR-204-5p |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |