Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | colon cancer tissues ,cells lines(DLD-1, HCT-8, HT-29, HCT-116, SW620, FHC, and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 level was obviously elevated in colon cancer cells.Silence of NEAT1 could greatly repress colon cancer cell progression. Apoptosis of colon cancer cells was triggered and the cell cycle progression was remarkably inhibited by downregulation of NEAT1.Interestingly, miR-495-3p was obviously decreased in colon cancer cells and it significantly suppressed colon cancer progression. Subsequently, miR-495-3p was predicted as a target of NEAT1. |
| Pubmed ID | 31173354 |
| Year | 2019 |
| Title | NEAT1 Promotes Colon Cancer Progression Through Sponging miR-495-3p and Activating CDK6 in Vitro and in Vivo |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |