Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | melanoma tissues ,cell lines(HEMa-LP, A375, A2058, SK-MEL-28, and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was overexpressed in melanoma cells.Overexpression of NEAT1 promoted the proliferation, migration, and invasion of melanoma cells.NEAT1 knockdown obviously restrained melanoma cell progression.NEAT1 could directly bind with miR-495-3p, which led to a negative effect on miR-495-3p levels.Furthermore, E2F3 was postulated as the target of miR-495-3p and overexpression of this miR could suppress the levels of E2F3. NEAT1 promoted melanoma progression in vivo via regulating the miR-495-3p/E2F3 axis. |
| Pubmed ID | 31173352 |
| Year | 2019 |
| Title | lncRNA NEAT1 Facilitates Melanoma Cell Proliferation, Migration, and Invasion via Regulating miR-495-3p and E2F3 |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |