Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, Luciferase reporter gene assay. |
| Sample | OSCC tissues, cell lines(HN4, Tca-8113, UM-SCC-1, Cal-27, SCC-25, SCCKN, hNOK) |
| Expression Pattern | up-regulated |
| Function Description | The present study demonstrated that expression of NEAT1 was significantly higher in OSCC tissue and cell lines compared with adjacent non-tumour tissue and normal oral keratinocytes, respectively. Additionally, upregulation of NEAT1 was significantly associ-ated with advanced clinical stage and shorter survival time in patients with OSCC. it was revealed that NEAT1 may downregulate microRNA (miR)-365 expression in OSCC cells. Further investigation indicated that increased NEAT1 expression was significantly associated with positive lymph node metastasis and advanced clinical stage. |
| Pubmed ID | 30186464 |
| Year | 2018 |
| Title | Long non-coding RNA NEAT1 promotes migration and invasion of oral squamous cell carcinoma cells by sponging microRNA-365. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |