Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | anaplastic thyroid cancer |
| ICD-0-3 | C73 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | ATC tissues, normal thyroid cell line (Nthy-ori 3-1) and ATC cell lines (SW1736 and 8505C) |
| Expression Pattern | up-regulated |
| Function Description | The present results demonstrated that NEAT1 was upregulated in ATC tissues and cell lines, and NEAT1 silencing resulted in decreased DDP resistance of ATC cells. In addition, NEAT1 suppressed miR 9 5p expres sion by binding to miR 9 5p and SPAG9 was a direct target of miR 9 5p. miR 9 5p overexpression sensitized ATC cells to DDP. Notably, NEAT1 silencing exerted its inhibitory effect on DDP resistance of ATC via the miR 9 5p/SPAG9 axis in vitro and in vivo. In conclusion, the present study demonstrated that NEAT1 silencing ameliorated DDP resistance of ATC, at least in part by reducing miR 9 5p sponging and regulating SPAG5 expression; |
| Pubmed ID | 31485599 |
| Year | 2019 |
| Title | LncRNA NEAT1 enhances the resistance of anaplastic thyroid carcinoma cells to cisplatin by sponging miR-9-5p and regulating SPAG9 expression |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for anaplastic thyroid cancer | OMIM COSMIC |