Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Adriamycin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues, cell lines (SGC7901, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was up-regulated in GC tissues and cells, especially in in GC adriamycin-resistant cells. NEAT1 silence in SGC7901 cells could inhibit proliferation and invasion ability, and promote cell apoptosis significantly.lncRNA NEAT1 is high-expressed in GC and functions as an oncogene to modulate apoptosis,invasion, proliferation and chemotherapy resistance of GC cells, which might be a novel potential therapeutic target for GC. |
| Pubmed ID | 28401449 |
| Year | 2017 |
| Title | Silence of Long Noncoding RNA NEAT1 Inhibits Malignant Biological Behaviors and Chemotherapy Resistance in Gastric Cancer. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |