Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | nasopharyngeal carcinoma tissues, cell lines (CNE1, CNE2, SUNE1, 6-10B, and SUNE2,N69,293T) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 knockdown inhibited proliferation and promoted apoptosis of NPC cells.NEAT1 was demonstrated to suppress miR-124 expression by direct interaction in NPC cells.miR-124 reversed NEAT1-mediated pro-proliferation and anti-apoptosis effect.miR-124 regulated NPC cell proliferation and apoptosis via NF-kB signal pathway. upregulated NEAT1 promoted the tumorigenesis and progression of NPC through regulating miR-124/NF-kB signaling pathway, suggesting an attractive therapy target for NPC patients. |
| Pubmed ID | 29270022 |
| Year | 2017 |
| Title | Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-kB pathway. |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |