Basic Information
| LncRNA/CircRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
| Region | GRCh38_11:65422774-65445540 |
| Ensemble | ENSG00000245532 |
| Refseq | NR_028272 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (Hep3B, LM3, MHCC97L, SK-hep1, HepG2, LO2, and HEK-293T ) |
| Expression Pattern | up-regulated |
| Function Description | Taken these together, we speculated that NEAT1 can modulate TGF-B1 expression by sponging hsa-mir-139-5p in HCC. These data indicates that targeting the NEAT1/hsamir-139-5p/TGF-B1 axis could be a new strategy for HCC |
| Pubmed ID | 29797561 |
| Year | 2018 |
| Title | NEAT1 upregulates TGF-B1 to induce hepatocellular carcinoma progression by sponging hsa-mir-139-5p |
External Links
| Links for NEAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |