Basic Information
LncRNA/CircRNA Name | NEAT1_2 |
Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC |
Region | GRCh38_11:65422774-65445540 |
Ensemble | ENSG00000245532 |
Refseq | NR_028272 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | papillary thyroid cancer |
ICD-0-3 | NA |
Methods | qPCR, RNAi, Western blot |
Sample | cell line (Nthy-ori 3-1, K1, IHH4, TPC1, BCPAP), PTC tissues |
Expression Pattern | up-regulated |
Function Description | The relative expression level of NEAT1_2 was positively associated with TNM stage and tumor size. NEAT1_2 knockdown led to a significant inhibition of growth and metastasis, and induced apoptosis in PTC cells. Knockdown of NEAT1_2 significantly inhibited malignant biological behavior by downregulating the oncogene ATAD2. NEAT1_2 could act as a competing endogenous RNA to regulate the expression of ATAD2 through downregulating miR-106b-5p. |
Pubmed ID | 29515109 |
Year | 2018 |
Title | NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer. |
External Links
Links for NEAT1_2 | GenBank HGNC NONCODE |
Links for papillary thyroid cancer | OMIM COSMIC |