Basic Information
| LncRNA/CircRNA Name | lncRNA-NEF |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | Hs 683 and CCD-25Lu human glioma cell lines, tumor tissues and adjacent heathy tissues, Blood |
| Expression Pattern | down-regulated |
| Function Description | NEF expression was downregulated in tumor tissues compared with adjacent heathy tissues. A low blood NEF level in patients with glioma effectively distinguished patients from healthy controls who had high blood NEF levels. Blood NEF levels were significantly correlation with distant tumor metastasis, but not tumor growth. Blood NEF levels were negatively correlated with blood transforming growth factor (TGF)-?1 levels in patients with distant tumor metastasis, but not in patients with non-metastatic glioma and healthy controls. NEF overexpression inhibited cancer cell migration and invasion. In addition, NEF overexpression downregulated TGF-?1 expression. |
| Pubmed ID | 31258706 |
| Year | 2019 |
| Title | lncRNA NEF inhibits glioma by downregulating TGF-?1 |
External Links
| Links for lncRNA-NEF | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |