Basic Information
| LncRNA/CircRNA Name | NIFK-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:121649650-121728481 |
| Ensemble | ENSG00000236859 |
| Refseq | NR_037856 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | macrophage | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Northern blot, Dual luciferase report system assays, RIP |
| Sample | endometrial cancer tissue, cell lines (Ishikawa, THP-1) |
| Expression Pattern | down-regulated |
| Function Description | The expression of NIFK-AS1 and miR-146a were decreased and increased in tumor-associated macrophages of endometrial cancer patients, Moreover, we found that NIFK-AS1 overexpression inhibited the 17?-estradiol-induced proliferation, migration and invasion of endometrial cancer cells through suppressing M2-like polarization of macrophages. |
| Pubmed ID | 30176290 |
| Year | 2018 |
| Title | Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a. |
External Links
| Links for NIFK-AS1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |