Basic Information
| LncRNA/CircRNA Name | NKILA |
| Synonyms | AK056098 |
| Region | GRCh38_20:57710183-57712780 |
| Ensemble | ENSG00000278709 |
| Refseq | NR_131157 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (KYSE30, KYSE70, KYSE150, KYSE180, KYSE450, KYSE510), ESCC tissues |
| Expression Pattern | down-regulated |
| Function Description | NF-kappaB-interacting lncRNA (NKILA) was remarkably upregulated by the classical TGF-B signaling pathway.NKILA is significantly downregulated in ESCC tumor tissues, and NKILA expression levels were significantly decreased in advanced tumor tissues (III and IV) compared to early stages (I and II).Gain- and NKILA inhibited ESCC cell metastasis in vitro and in vivo, and NKILA repressed MMP14 expression by inhibiting IkBa phosphorylation and NF-kB activation. Collectively,the TGF-B-induced lncRNA NKILA has potential as an antimetastasis therapy.Long noncoding RNA NKILA could be remarkably upregulated by classicalTGF-B signal pathway in ESCC.NKILA was significantly downregulated in esophageal squamous cell carcinoma and negatively correlated with TNM stage. |
| Pubmed ID | 29379981 |
| Year | 2018 |
| Title | TGF-B-induced NKILA inhibits ESCC cell migration and invasion through NF-kB/MMP14 signaling |
External Links
| Links for NKILA | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |