Basic Information
| LncRNA/CircRNA Name | NNT-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:43571594-43603230 |
| Ensemble | ENSG00000248092 |
| Refseq | NR_073113 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Luciferase reporter assay, RIP etc |
| Sample | cell lines (RT-4, UM-UC-3, J82, T24) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that NNT-AS1 was upregulated in BC cells.In addition, we found that miR-1301-3p targeted to PODXL. PODXL expression downregulated in NNT-AS1-silenced cells was restored by miR-1301-3p inhibition. Importantly, NNT-AS1 was discovered to activate Wnt pathway, and the treatment of LiCl recovered the repressive role of NNT-AS1 silencing in BC cell growth. Through restoration assays, we observed that PODXL overexpressing countervailed NNT-AS1 depletion-mediated suppression on BC cell growth and Wnt pathway. |
| Pubmed ID | 31782983 |
| Year | 2019 |
| Title | NNT-AS1 Enhances Bladder Cancer Cell Growth by Targeting miR-1301-3p/PODXL Axis and Activating Wnt Pathway |
External Links
| Links for NNT-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |