Basic Information
| LncRNA/CircRNA Name | NNT-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:43571594-43603230 |
| Ensemble | ENSG00000248092 |
| Refseq | NR_073113 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | osteosarcoma tissues, cell lines (hFOB1.19, U2OS, Saos2, OS-9901, SOSP-9607, MG-63 and OS-732) |
| Expression Pattern | up-regulated |
| Function Description | the expression of NNT-AS1 was significantly increased in tumor tissues compared to adjacent normal tissues. upregulated NNT-AS1 expression predicted poor prognosis and was an independent and significant risk factor for osteosarcoma patient survival. NNT-AS1 knockdown significantly inhibited cell proliferation by inducing cell cycle arrest and promoting apoptosis in osteosarcoma cells. NNT-AS1 silencing suppressed cell migration and invasion in vitro.knockdown of NNT-AS1 suppressed tumor growth of OS-732 cells in vivo.NNT-AS1 functions as an oncogene in osteosarcoma and could be a novel diagnostic and therapeutic target for osteosarcoma. |
| Pubmed ID | 29518771 |
| Year | 2018 |
| Title | Overexpression of Long Non-Coding RNA NNT-AS1 Correlates with Tumor Progression and Poor Prognosis in Osteosarcoma. |
External Links
| Links for NNT-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |