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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating	2
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	epithelial ovarian cancer
ICD-0-3	C56.9
Methods	qPCR, Luciferase reporter assay, in vitro knockdown
Sample	An immortal normal human ovarian epithelial cell line, HS832.Tc, and seven human EOC cell lines, SK-OV-3, CAOV-3, CAOV-4, OVCAR-3, HEY-T30, ES-2, and SW/626, EOC tumor samples and paired adjacent non-tumor samples
Expression Pattern	up-regulated
Function Description	NORAD was substantially upregulated in both EOC cell lines and human tumors. In OVCAR-3 and ES-2 cells, lentivirus-mediated NORAD downregulation had significant anticancer effects, as it suppressed cell proliferation, decreased bufalin chemoresistance, arrested cell-cycle transition, and inhibited xenograft growth. Also, hsa-miR-155-5p was confirmed to be the competing target of NORAD in EOC, and its knockdown in OVCAR-3 and ES-2 cells reversed the NORAD downregulation-induced anticancer functions
Pubmed ID	31250987
Year	2019
Title	Long noncoding RNA NORAD is upregulated in epithelial ovarian cancer and its downregulation suppressed cancer cell functions by competing with miR-155-5p

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