Basic Information
| LncRNA/CircRNA Name | BC087858 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay, Cell apoptosis assay etc. |
| Sample | NSCLC tissues, cell lines (PC9, H1975, H460 and H23) |
| Expression Pattern | up-regulated |
| Function Description | Over-expression was observed in NSCLC cells and patients with acquired resistance to EGFR-TKIs and significantly associated with a shorter progression-free survival (PFS) in tumors with respond to EGFR-TKIs. The significant relationship was not observed in patients with T790M mutation but in patients with non-T790M. Down-regulation of BC087858 could significantly promote PC9/R and PC9/G2 cells invasion. BC087858 knockdown restored gefitinib sensitivity in acquired resistant cells with non-T790M and inhibited the activation of the PI3K/AKT and MEK/ERK pathways and epithelial-mesenchymal transition (EMT) via up-regulating ZEB1 and Snail. |
| Pubmed ID | 27409677 |
| Year | 2016 |
| Title | Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer. |
External Links
| Links for BC087858 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |