Basic Information
| LncRNA/CircRNA Name | NR_023387 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, other |
| Sample | renal cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | Methylation-specific PCR, MassARRAY, and demethylation drug treatment indicated that hypermethylation in the NR_023387 promoter contributed to its silencing in RCC. Besides, HNF4A regulated the expression of NR_023387 via transcriptional activation. Functional experiments demonstrated NR_023387 exerted tumor-suppressive roles in RCC via suppressing the proliferation, migration, invasion, tumor growth, and metastasis of RCC. Furthermore, we identified MGP as a putative downstream molecule of NR_023387, which promoted the epithelial-mesenchymal transition of RCC cells. Our study provides the first whole-genome lncRNA methylation profile in RCC. |
| Pubmed ID | 31432508 |
| Year | 2020 |
| Title | Silencing of Tumor-Suppressive NR_023387 in Renal Cell Carcinoma via Promoter Hypermethylation and HNF4A Deficiency |
External Links
| Links for NR_023387 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |