Basic Information
| LncRNA/CircRNA Name | BC200 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000236824 |
| Refseq | NR_001568 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR, fluorescence microscopy etc. |
| Sample | human tongue squamous carcinoma cell line, TCA8113 |
| Expression Pattern | down-regulated |
| Function Description | Using the tongue carcinoma cell line,we showed that forced expression of ECRG4 down-regulated the expression of the BC200 long non-coding RNA (lncRNA) and matrix metalloproteinases (MMP-9 and MMP-13). Restoration of BC200 lncRNA rescued ECRG4-mediated down-regulation of MMP-9 and -13. Furthermore, over-expression of Ecrg4 inhibited cell proliferation and migration, which was abolished by forced expression of BC200 lncRNA in TCA8113 cells. |
| Pubmed ID | 31152845 |
| Year | 2019 |
| Title | Esophageal Cancer Related gene-4 Inhibits the Migration and Proliferation of Oral Squamous Cell Carcinoma Through BC200 lncRNA/MMP-9 and -13 Signaling Pathway |
External Links
| Links for BC200 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |