Basic Information
LncRNA/CircRNA Name | NR2F1-AS1 |
Synonyms | NA |
Region | GRCh38_5:93409359-93585648 |
Ensemble | ENSG00000237187 |
Refseq | NR_021490 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | hepatocellular carcinoma |
ICD-0-3 | C22.0 |
Methods | qPCR, Microarray, Western blot etc. |
Sample | cell lines (Huh7, HepG2, Lo-2), HCC tissues |
Expression Pattern | up-regulated |
Function Description | miR-363 targeted the 3'-UTR of NR2F1-AS1 and ABCC1 mRNA,presenting that NR2F1-AS1 promoted ABCC1 expression through endogenous sponging miR-363.NR2F1-AS1 regulates HCC OXA resistance through targeting miR-363-ABCC1 pathway,providing a vital theoretic mechanism and therapeutic target for HCC chemoresistance. |
Pubmed ID | 29602203 |
Year | 2018 |
Title | LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363. |
External Links
Links for NR2F1-AS1 | GenBank HGNC NONCODE |
Links for hepatocellular carcinoma | OMIM COSMIC |