Basic Information
| LncRNA/CircRNA Name | NR2F2-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:96110040-96327361 |
| Ensemble | ENSG00000247809 |
| Refseq | XR_109225 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | CRC cancer and non-cancer tissues,cell lines (RKO and CR4) |
| Expression Pattern | up-regulated |
| Function Description | Our data showed that NR2F2-AS1 was upregulated in CRC and CRC patients with high levels of NR2F2-AS1 showed a low overall survival rate. Cyclin D1 was also upregulated in CRC and a positive correlation was found between Cyclin D1 and NR2F2-AS1. In CRC cells, NR2F2-AS1 siRNA silencing mediated the downregulation of Cyclin D1 and G0/G1 arrest, while Cyclin D1 overexpression rescued G0/G1 arrest caused by NR2F2-AS1 siRNA silencing. |
| Pubmed ID | 32210626 |
| Year | 2020 |
| Title | LncRNA NR2F2-AS1 Silencing Induces Cell Cycle Arrest in G0/G1 Phase via Downregulating Cyclin D1 in Colorectal Cancer |
External Links
| Links for NR2F2-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |