Basic Information
| LncRNA/CircRNA Name | NR2F2-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:96110040-96327361 |
| Ensemble | ENSG00000247809 |
| Refseq | XR_109225 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, other |
| Sample | CRC tissues and cell lines (CR4, RKO) |
| Expression Pattern | up-regulated |
| Function Description | We found that NR2F2-AS1 and cyclin-dependent kinase 6 (CDK6) were both upregulated in CRC and were positively correlated. NR2F2-AS1 siRNA silencing led to downregulated CDK6 and induced Gap 1 (G1) arrest of CRC cells. CDK6 overexpression rescued G1 arrest caused by NR2F2-AS1 siRNA silencing. High expression levels of NR2F2-AS1 were closely correlated with low overall 5-year survival rate. NR2F2-AS1 siRNA silencing led to decreased rate of CRC cell proliferation. CDK6 overexpression attenuated the effects of NR2F2-AS1 siRNA silencing on cancer cell proliferation. |
| Pubmed ID | 31432342 |
| Year | 2020 |
| Title | Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6 |
External Links
| Links for NR2F2-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |