Basic Information
| LncRNA/CircRNA Name | NRG1 |
| Synonyms | NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF |
| Region | GRCh38_8:31639386-32767959 |
| Ensemble | ENSG00000157168 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | High expression was observed in cancer tissues, which was consistent with our previous study that NRG1 was highly expressed in lung cancer induced by nickel. NRG1 was located on chromosome 2q12, within intron2 of ADAMTS6, a disintegrin and metalloproteinase with thrombospondin motifs. And, NRG1 had a high level of homology (76 %) to rat LINE1 sequence RL1.3 (long interspersed middle repetitive DNA) |
| Pubmed ID | 22665269 |
| Year | 2012 |
| Title | Isolation and characterization of a novel noncoding RNA from nickel-induced lung cancer. |
External Links
| Links for NRG1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |