Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | colorectal cancer cell lines (LoVo and SW480) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA OIP5-AS1 and DYRK1A were down-regulated in radio-resistant CRC cell lines. Survival analysis showed that lowerOIP5-AS1 orDYRK1Aexpressing CRC had a poorer prognosis. OIP5-AS1 suppressed the expression of miR-369-3p, thus up-regulating DYRK1A, the downstream gene of miR-369-3p. OIP5-AS1 and DYRK1A impaired cell clonogenic survival and promoted cell apoptosis after irradiation, improving radiosensitivity of CRC cells. |
| Pubmed ID | 29773344 |
| Year | 2018 |
| Title | LncRNA OIP5-AS1 Regulates Radioresistance by Targeting DYRK1A Through miR-369-3p in Colorectal Cancer Cells |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |