Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot analysis, Luciferase reporter assay |
| Sample | gastric tissues, cell lines MKN45, MGC803, BGC823, SGC7901, AGS,GES-1 |
| Expression Pattern | up-regulated |
| Function Description | OIP5-AS1 expression was up-regulated in GC tissues and cell lines, which significantly correlated with unfavorable clinical characteristics and shorter survival. The results of in vitro and in vivo gain- and loss-of-function experiments indicate that OIP5AS1 promoted cell proliferation and colony formation while inhibiting apoptosis of GC cells. OIP5-AS1 functioned as an endogenous sponge for miR-367-3p in GC cells. |
| Pubmed ID | 31959478 |
| Year | 2020 |
| Title | Long Non-Coding RNA OIP5-AS1 Promotes the Growth of Gastric Cancer Through the miR-367-3p/HMGA2 Axis |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |