Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | Human CC cells (C33A, SiHa, HeLa, CaSki, ME-180),cervical epithelial cell line (Ect1/E6E7) |
| Expression Pattern | up-regulated |
| Function Description | In the current study,we found that lncRNA OIP5-AS1 was upregulated in CC tissues and cell lines. Moreover, we revealed that OIP5-AS1 could act as a competing endogenous RNA of miR-143-3p to regulate the ITGA6 expression. we found that the OIP5-AS1 expression was significantly upregulated in patients with CC with advanced FIGO stageand lymph node metastasis. |
| Pubmed ID | 30188591 |
| Year | 2018 |
| Title | Long noncoding RNA opa-interacting protein 5 antisensetranscript 1 promotes proliferation and invasion throughelevating integrin?6 expression by sponging miR-143-3p incervical cancer. |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |