Basic Information
| LncRNA/CircRNA Name | OIP5-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000247556 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Luciferase Reporter Assay, Western blot |
| Sample | osteosarcoma tissues, cell lines (Saos-2, MG63, 143B, U2-OS, hFOB) |
| Expression Pattern | up-regulated |
| Function Description | Results revealed that OIP5-AS1 level was elevated in osteosarcoma tissue and cells. Clinically, OIP5-AS1 high-expression was closely correlated with osteosarcoma patients' poor prognosis. Mechanistically, silenced OIP5-AS1 expression significantly repressed the proliferative ability and accelerated the apoptosis, miR-223 was predicted to target the 3'-UTR of OIP5-AS1 and constituted RNA induced silencing complex. |
| Pubmed ID | 30119217 |
| Year | 2018 |
| Title | Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223. |
External Links
| Links for OIP5-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |