Basic Information
| LncRNA/CircRNA Name | OPI5-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Luciferase Reporter Gene Assay, Western blot |
| Sample | GC tissues and matched epithelial tissues,gastric epithelial cell line (RGM-1), gastric cancer cell lines (HCG-27 and SGC-7901), and HEK293T cells |
| Expression Pattern | up-regulated |
| Function Description | OPI5-AS1 was significantly upregulated, while miR-641 was downregulated in GC tissues and cells. OPI5-AS1 expression was remarkably inversely correlated with miR-641 in GC. Moreover, OPI5-AS1 could sponge miR-641 and regulate its expression in GC cells. Functional experiments showed that OPI5-AS1 overexpression remarkably accelerated GC cell proliferation and cell cycle. |
| Pubmed ID | 31858545 |
| Year | 2019 |
| Title | Long Non-Coding RNA OIP5-AS1 Promotes Proliferation of Gastric Cancer Cells by Targeting miR-641 |
External Links
| Links for OPI5-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |