Basic Information
| LncRNA/CircRNA Name | P2RX7-V3 |
| Synonyms | P2RX7, P2X7 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | cell lines (MUM2B, OM431, and 293T) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identified a transcriptional variant transcribed from the P2RX7 gene locus, named P2RX7-V3 (P2RX7 variant 3), which was expressed at a high level in UM cells. P2RX7-V3 silencing revealed that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppressed tumor growth in vitro and in vivo. |
| Pubmed ID | 27468714 |
| Year | 2016 |
| Title | P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma. |
External Links
| Links for P2RX7-V3 | GenBank HGNC NONCODE |
| Links for uveal melanoma | OMIM COSMIC |