Basic Information
| LncRNA/CircRNA Name | P53RRA |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell lines (HBE, MRC-5, A549, H358 ,H522 ), non-small-cell lung cancer tissue |
| Expression Pattern | down-regulated |
| Function Description | P53RRA promoted ferroptosis and apoptosis by affecting transcription of several metabolic genes. Low P53RRA expression significantly correlated with poor survival in patients with breast and lung cancers harboring wild-type p53. |
| Pubmed ID | 29588351 |
| Year | 2018 |
| Title | A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53. |
External Links
| Links for P53RRA | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |