Basic Information
| LncRNA/CircRNA Name | BC200 |
| Synonyms | BCYRN1, BC200, BC200a, LINC00004, NCRNA00004 |
| Region | GRCh38_2:47335315-47335514 |
| Ensemble | ENSG00000236824 |
| Refseq | NR_001568 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, ChIP etc. |
| Sample | cell lines (MCF-7, T47D, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we show that BC200 is upregulated in breast cancer; among breast tumor specimens there is a higher level of BC200 in estrogen receptor (ER) positive than in ER-negative tumors. Further experiments show that activation of estrogen signaling induces expression of BC200. |
| Pubmed ID | 27277684 |
| Year | 2016 |
| Title | Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. |
External Links
| Links for BC200 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |