Basic Information
| LncRNA/CircRNA Name | PANDAR |
| Synonyms | PANDAR, PANDA |
| Region | GRCh38_6:36673621-36675126 |
| Ensemble | ENSG00000281450 |
| Refseq | NR_109836 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | lung cancer tissues, cell lines (A549, SPC-A1, NCI-H1299, SK-MES-1 etc.) |
| Expression Pattern | down-regulated |
| Function Description | In a cohort of 140 NSCLC patients, decreased PANDAR expression was negatively correlated with greater tumor size and advanced TNM stage. Moreover, PANDAR could serve as an independent predictor for overall survival in NSCLC. PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. |
| Pubmed ID | 25719249 |
| Year | 2015 |
| Title | Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2. |
External Links
| Links for PANDAR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |