Basic Information
| LncRNA/CircRNA Name | PARROT |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (HeLa, HEK293 and A549) |
| Expression Pattern | differential expression |
| Function Description | To address effects on migration, in addition to cell growth, we used A549 cells. A549 cells display reduced migration ability following knock-down of PARROT. The effect on cellular migration is comparable to knock-down of SNAI1, a known regulator of cellular migration (quantified from three independent experiments, demonstrating a general function of PARROT in several cell lines and effects on both cell growth and migration. |
| Pubmed ID | 27129154 |
| Year | 2016 |
| Title | The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation. |
External Links
| Links for PARROT | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |