Basic Information
LncRNA/CircRNA Name | PART1 |
Synonyms | NA |
Region | GRCh38_5:60487713-60547657 |
Ensemble | ENSG00000152931 |
Refseq | NR_024617 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qRT-PCR, Western blot.Luciferase Reporter Assay, RIP |
Sample | CRC tissues,colorectal cell (NCM460) and colorectal cancer cells (HCT-116,SW116, SW480 and HT29) |
Expression Pattern | up-regulated |
Function Description | PART1 was up-regulated in CRC tissues and cell lines. Inhibition of PART1 hindered CRC cell proliferation, invasion and migration, while promoting CRC cell apoptosis.PART1 sponged miR-150-5p/miR-520 h to up-regulate CTNNB1, thus activating Wnt/?-catenin pathway in CRC. |
Pubmed ID | 31669140 |
Year | 2020 |
Title | LncRNA PART1 Regulates Colorectal Cancer via Targeting miR-150-5p/miR-520h/CTNNB1 and Activating Wnt/?-catenin Pathway |
External Links
Links for PART1 | GenBank HGNC NONCODE |
Links for colorectal cancer | OMIM COSMIC |