Basic Information
| LncRNA/CircRNA Name | PART1 |
| Synonyms | NA |
| Region | GRCh38_5:60487713-60547657 |
| Ensemble | ENSG00000152931 |
| Refseq | NR_024617 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Bladder Cancer |
| ICD-0-3 | C67 |
| Methods | Microarray, qPCR |
| Sample | Human bladder cancer cell lines (5637, T24), bladder cancer samples and matched adjacent normal bladder tissues |
| Expression Pattern | up-regulated |
| Function Description | Prostrate androgen-regulated transcript-1 expression was upregulated in bladder cancer tissues compared to adjacent nontumor tissues. Furthermore, prostrate androgen-regulated transcript-1 levels were successfully upregulated by pcDNA3.1-prostrate androgenregulated transcript-1 and depleted by pCMV-sh prostrate androgen-regulated transcript-1 in bladder cancer cell lines (5637, T24). Enhanced prostrate androgen-regulated transcript-1 expression promoted cell proliferation and invasion and inhibited cell apoptosis. However, knockdown of prostrate androgen-regulated transcript-1 expression inhibited cell proliferation and invasion and induced cell apoptosis. |
| Pubmed ID | 31311442 |
| Year | 2019 |
| Title | Downregulated Long Noncoding RNA PART1 Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer |
External Links
| Links for PART1 | GenBank HGNC NONCODE |
| Links for Bladder Cancer | OMIM COSMIC |