Basic Information
| LncRNA/CircRNA Name | PARTICLE |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NR_038942 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi etc. |
| Sample | cell line (MDA-MB-361, 24 hr) |
| Expression Pattern | differential expression |
| Function Description | In silico analysis identified additional regions for PARTICLE triplexes at >1600 genomic locations. Multiple PARTICLE triplexes are clustered predominantly within the human and mouse tumor suppressor WW Domain Containing Oxidoreductase (WWOX) gene. Surface plasmon resonance diffraction and electrophoretic mobility shift assays were consistent with PARTICLE triplex formation within human WWOX with high resolution imaging demonstrating its enrichment at this locus on chromosome 16. PARTICLE knockdown and over-expression resulted in inverse changes in WWOX transcripts levels with siRNA interference eliminating PARTICLEs elevated transcription to irradiation. The evidence for a second functional site of PARTICLE triplex formation at WWOX suggests that PARTICLE may form triplex-mediated interactions at multiple positions in the human genome including remote loci. |
| Pubmed ID | 28769061 |
| Year | 2017 |
| Title | PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome. |
External Links
| Links for PARTICLE | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |