Basic Information
| LncRNA/CircRNA Name | PAS1 |
| Synonyms | PHACTR2-AS1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay, Microarray etc |
| Sample | breast cancer tissues,cell line(MCF7, MDA-MB-231, Hs578T, HEK-293A) |
| Expression Pattern | down-regulated |
| Function Description | PHACTR2-AS1 was downregulated in breast cancer patients, where lower PHACTR2-AS1 expression promoted breast cancer development and correlated with poor patient outcome. Taken together, we demonstrate that PHACTR2-AS1 maintains a H3K9 methylation-marked silent state of ribosomal DNA genes, comprising a regulatory axis that controls breast cancer growth and metastasis. |
| Pubmed ID | 32312833 |
| Year | 2020 |
| Title | The EZH2-PHACTR2-AS1-ribosome Axis Induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer |
External Links
| Links for PAS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |