Basic Information
| LncRNA/CircRNA Name | PAUPAR |
| Synonyms | PAUPAR |
| Region | GRCh38_11:31812307-32002405 |
| Ensemble | ENSG00000281880 |
| Refseq | NR_117094 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cell lines (MUM2B, OCM1, OM431) |
| Expression Pattern | down-regulated |
| Function Description | The ectopic expression of PAUPAR in UM cells revealed that PAUPAR acts as a necessary UM suppressor and induces the silencing of HES1 expression, which significantly reduces tumour metastasis. Mechanistically, PAUPAR modulates HES1 expression by inhibiting histone H3K4 methylation. |
| Pubmed ID | 27214741 |
| Year | 2016 |
| Title | PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma. |
External Links
| Links for PAUPAR | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |